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Rapid sequestration and prolonged retention of intravenously injected nanoparticles by the liver and spleen (reticuloendothelial system (RES)) presents a major barrier to effective delivery to the target site and hampers clinical translation of nanomedicine. Inspired by biological macromolecular drugs, synthesis of ultrasmall (diameter ≈12–15 nm) porous silica nanoparticles (UPSNs), capable of prolonged...
While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator‐free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom‐up synthesized WS2 nanoflakes, this study fabricates a unique type of WS2/WOx nanodots,...
The engineering of a novel dual‐modality imaging probe is reported here by intrinsically labeling zirconium‐89 (89Zr, a positron emission radioisotope with a half‐life of 78.4 h) to PEGylated Gd2O2S:Eu nanophorphors, forming [89Zr]Gd2O2S:Eu@PEG for in vivo positron emission tomography/radioluminescence lymph node mapping.
Optical imaging has been the primary imaging modality for nearly all of the renal clearable nanoparticles since 2007. Due to the tissue depth penetration limitation, providing accurate organ kinetics non‐invasively has long been a huge challenge. Although a more quantitative imaging technique has been developed by labeling nanoparticles with single‐photon emission computed tomography (SPECT) isotopes,...
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