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To investigate the roles of TRPV1 and TRPA1 channels in baseline and allyl isothiocyanate (AITC)-evoked nociceptive responses by comparing wild-type and gene-deficient mice.In contrast to conventional methods of thermonociception measuring reflex latencies, we used our novel methods to determine the noxious heat threshold.It was revealed that the heat threshold of the tail measured by an increasing-temperature...
The mechanisms by which topical mustard oil causes vasodilatation in the mouse were investigated using the tachykinin NK 1 receptor antagonist SR140333 and the calcitonin gene-related peptide (CGRP) antagonist BIBN4096BS, alongside αCGRP or NK 1 receptor knockout mice. Blood flow was assessed by laser Doppler flowmetry and plasma extravasation by 125 I-albumin accumulation...
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