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Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst 4 ). In the present study, the antinociceptive effects of a novel somatostatin sst 4 receptor selective peptidomimetic compound, J-2156 (1–100 μg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase...
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