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Dopaminergic human neuroblastoma SH-SY5Y cells were stably transformed to increase expression of α-synuclein, a Parkinson’s disease-related protein. Transformed cells were more resistant to oxidative insults, showing a cytoprotective role of α-synuclein. The expression of redox chaperonins (DJ-1, HSP70, and 14-3-3) was evaluated by Western blotting. Expression of α-synuclein reduced HSP70 levels even...
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