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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the pacemaker currents (I f ) in cardiac cells. The objectives of this study were to investigate the electropharmacological activity of amiodarone on human HCN channels heterologously expressed in Xenopus laevis oocytes. hHCN channels were expressed in oocytes and studied using the standard two-electrode voltage-clamp...
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