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Rituximab is a monoclonal antibody to CD20, an antigen found on B cells. It was developed for the treatment of B cell lymphomas but was subsequently found useful in a number of autoimmune disorders. The efficacy of rituximab varies with the maturity and location of the target B cells, nature of the effector cells, pharmacokinetic considerations, time to B cell depletion and time to B cell restoration...
Le rituximab (RTX) est un anticorps (Ac) monoclonal dirigé contre CD20 qui est spécifique des lymphocytes B (LB). Ses indications ont initialement été limitées aux lymphomes B, puis étendues aux maladies auto-immunes. Toutefois, son efficacité varie en fonction du degré de maturité et de la localisation des LB cibles, de la nature des cellules effectrices, de données pharmacocinétiques, du retard...
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