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20-HETE is a potent inducer of endothelial ACE in vitro and administration of lisinopril or losartan attenuates blood pressure in models of 20-HETE-dependent hypertension. The present study was undertaken to further define the relationship between 20-HETE and the renin–angiotensin system in hypertension using an angiotensinogen-deficient mouse (Agt+/−). Treatment of male AGT+/− with 5α-dihydrotestosterone...
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