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Background
Prostate‐specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is an important diagnostic and therapeutic target in prostate cancer. PSMA/GCPII is also expressed in many healthy tissues, but its function has only been established in the brain and small intestine. Several research groups have attempted to produce PSMA/GCPII‐deficient mice to study the physiological...
BACKGROUNDGlutamate carboxypeptidase II (GCPII) is a transmembrane enzyme that cleaves N‐acetyl‐L‐aspartyl‐L‐glutamate (NAAG) in the brain. GCPII is highly expressed in the prostate and prostate cancer and might be associated with prostate cancer progression. Another exopeptidase, plasma glutamate carboxypeptidase (PGCP), was reported to be similar to GCPII and to share its NAAG‐hydrolyzing activity...
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