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d-Serine plays a key role in glutamatergic neurotransmission in mammalian brain as a co-agonist of N-methyl-d-aspartate receptors. The enzyme responsible for d-serine biosynthesis, serine racemase (SR), is therefore a promising target for treatment of neuropathologies related to glutamate receptor excitotoxicity, such as stroke or Alzheimer’s disease. Much of the experimental work to date has been...
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