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Most antibacterial peptides exhibit low therapeutic indices in vivo. Peptide A3‐APO was shown to exhibit high potency against Escherichia coli bacteremia when added intraperitoneally. To extend the studies to systemic infections against multidrug‐resistant organisms, we studied the efficacy of A3‐APO in mouse models of carbapenem‐resistant Acinetobacter baumannii infection. When administered either...
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