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The prolongation of action potential duration (APD) is usually related to conditions of low repolarization reserve and leads to long QT syndrome. In these situations, an unbalance between currents can fire early after depolarizations (EADs). This repolarizing disorder has been observed in heart failure situations, where the late sodium current (INaL) has an important role. In this work we evaluate...
The aim of this study was to investigate interactions between acquired long QT syndrome by dofetilide and reduced repolarization reserve in simulated human ventricular cells using prolongation of APD and triangulation of action potential. A Markovian model of hERG capable of reproducing a wild type as well an acquired long QT syndrome by dofetilide was developed and was included into a ventricular...
Torsades de pointes (TdP) is a life-threatening ventricular tachycardia associated to reduction of the rapid delayed rectifier potassium current (IKr) and prolongation of ventricular action potential duration (APD) and long QT (LQT) syndrome. An abnormal increase of the late sodium current (INaL) is also associated to susceptibility to TdP. In this work, a mathematical model of INaL has been proposed...
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