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We investigated K + currents and their regulation by the sarcoplasmic reticulum in mesenteric arterial smooth muscle cells of the spontaneously hypertensive rat (SHR). Using perforated patch-clamp technique, we found the overall K + current density was significantly lower in adult SHR compared to adult Wistar–Kyoto rats (WKY). The K + currents were almost exclusively of large-conductance...
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