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The syntheses and characterization of C4 and C5 substituted N,N′-bis(arylmethyl)imidazolium salts with hydrophilic or lipophilic substituents on the imidazole ring are reported. A structure-activity relationship study revealed that the lipophilicity of groups at the C4 and C5 positions plays a crucial role in modulating the efficacy against select non-small cell lung cancer cell lines tested. Compounds...
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