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Long QT syndrome is a repolarization disorder characterized by marked prolongation of QT interval. A clear consequence of long QT syndrome is the occurrence of a polymorphic ventricular tachycardia called Torsade de Pointes, which has been related to early after depolarizations (EADs) formation. This repolarizing disorder has been observed under pathological situations, such as heart failure, oxidative...
Computer simulations have been used to study the mechanisms of postrepolarization refractoriness in cardiac cells under ischemic conditions at the cellular level. The ten Tusscher model of the cardiac action potential has been used with the formulation of the ATP-sensitive K+ current by Ferrero et al being adopted. Cells were subjected to hyperkalemia, hypoxic and acidic conditions. The results show...
Trace element determination can be applied in forensic medicine to diagnose the cause of death. Drowning is the second leading cause of death from unintentional injury. Despite the many diagnostic methods used, the post-mortem diagnosis of drowning continues to be one of the most difficult in forensic pathology. Strontium is a highly sensitive marker of water aspiration in a liquid medium rich in...
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