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Exposure of the human muco-epidermoid carcinoma derived cell line H292 to TNF, LPS or IL-1 along with cycloheximide (CHI) superinduces IL-6 and IL-8 mRNA. Superinduction results from an increased transcription and an increased stability of IL-6 and IL-8 mRNA. TNF, LPS and IL-1-induced IL-6 and IL-8 expression is inhibited by the corticosteroid dexamethasone (Dex). Here we studied the effect of Dex...
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