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Objectives: To examine morphological similarities between classically different congenital heart lesion types induced in fetal rats by the cardiac teratogen N,N -bis(dichloroacetyl)-1,8-octamethylenediamine (bis-diamine). Methods: A single 200 mg oral dose of bis-diamine was given to 50 pregnant rats on the 9th gestational day. Eleven controls were fed an inert vehicle. Experimental and control...
Objectives: To study the development of aortic to mitral fibrous continuity in the normal rat heart. Methods: The hearts and great vessels of normally developed rat embryos and fetuses aged between 13.25 and 19.75 days of gestation were studied in conjunction with those of newborns aged 2 and 7 days post-partum. Standard histological methods and monoclonal antibodies raised against alpha smooth...
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