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Menstrual toxic shock syndrome (MTSS) is a severe toxin‐mediated disease associated with Staphylococcus aureus producing toxic shock syndrome toxin 1 (TSST‐1), a superantigen that mediates a potent activation of Vβ‐2 T cells. In animal models, superantigen treatment of responsive T cells induces their initial proliferation, followed by unresponsiveness upon further superantigen stimulation. To determine...
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