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The crystal structures of the Ca 2+ - and H + -ATPases shed light into the membrane embedded domains involved in binding and ion translocation. Consistent with site-directed mutagenesis, these structures provided additional evidence that membrane-spanning segments M4, M5, M6 and M8 are the core through which cations are pumped. In the present study, we have used alanine/serine scanning...
Of the four transmembrane helices (M4, M5, M6, and M8) that pack together to form the ion-binding sites of P 2 -type ATPases, M8 has until now received the least attention. The present study has used alanine-scanning mutagenesis to map structure–function relationships throughout M8 of the yeast plasma-membrane H + -ATPase. Mutant forms of the ATPase were expressed in secretory vesicles...
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