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Infectious particles of influenza A virus (IAV) typically contain eight unique negative-strand viral RNA (vRNA) segments. It has been suggested that the selective packaging of IAV segments occurs through RNA-RNA interactions between different vRNA segments, and that local secondary structures formed within vRNA segments are involved in such interactions. PB2 segment plays a critical role in the viral...
Recombination plays an important role in shaping the genetic diversity of a number of DNA and RNA viruses. Although some recent studies have reported bioinformatic evidence of mosaic sequences in a variety of influenza A viruses, it remains controversial as to whether these represent bona fide natural recombination events or laboratory artifacts. Importantly, mosaic genome structures can create significant...
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