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Serotype 1 strains of Marek’s disease virus (MDV-1) cause malignant lymphomas in chickens (Marek’s disease; MD). Although MD has been controlled by vaccination, field isolates of MDV-1 have tended to increase in virulence and cause MD even in vaccinated chickens. Meq, a putative MDV-1 oncoprotein, resembles the Jun/Fos family of basic leucine zipper (bZIP) transcription factors and can regulate the...
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