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Introduction Atenolol, a commonly prescribed β blocker for hypertension, is also associated with adverse cardiometabolic effects such as hyperglycemia and dyslipidemia. Knowledge of the mechanistic underpinnings of these adverse effects of atenolol is incomplete. Objective We sought to identify biomarkers associated with risk for these untoward effects of atenolol. We measured baseline blood serum...
Selection of antihypertensive therapy is often empiric, and use of genetic information to guide drug therapy selection holds future promise.The objective of this trial is to identify the genetic determinants of the antihypertensive and adverse metabolic responses to a thiazide diuretic (hydrochlorothiazide), a β-blocker (atenolol), and their combination. This will be accomplished through candidate...
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