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Die komplexe Wechselbeziehung zwischen altersassoziierten Veränderungen der Physiologie und funktionellen Defiziten beeinflusst bei älteren Patienten pharmakokinetische, pharmakodynamische Aspekte sowie Aspekte des Therapiemangements insgesamt. Häufig liegt Multimorbidität und eine sich daraus ergebende Polypharmazie mit der Gefahr unübersichtlicher Medikamenteninteraktionen vor. Des Weiteren bestehen...
Due to increasing incidence of chronic diseases with advancing age, drugs are predominantly prescribed to elderly patients. But there is a lack of data, representing this age group. As the aging organism shows various physiologic changes that may influence pharmacokinetic parameters, an individualized risk-benefit-analysis is warranted. Moreover, functional limitations may bare additional risks of...
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