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Interleukin (IL-)6 and IL-11 signal via homodimeric gp130 receptors, IL-6Rα and IL-11Rα, respectively. Preferential basolateral localization was demonstrated for the IL-6R and gp130. IL-11R is expressed in polarized cells cells as well. Moreover, IL-11 is involved in development of gastric tumors and regeneration of colon and heart tissue. Here, we show that the heterologous expression of IL-11R1...
Activation of the transcription factors STAT5A and STAT5B by JAK1 and JAK3 tyrosine kinases is a key event in downstream signaling of γc (common gamma chain)-family cytokine receptors in lymphoid cells. STAT5A/B-deficiency in mice causes, among other consequences, a reduced size and altered composition of the peripheral T-cell pool with predominance of an activated or memory-like population (CD4 ...
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