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Activation of Stat5 is frequently found in leukemias. To study the mechanism and role of Stat5 activation, we introduced a constitutively activated Stat5a mutant, cS5 F , into murine bone marrow (BM) cells. BM transplantation with cS5 F -transfected cells caused development of multilineage leukemias in lethally irradiated wild-type or nonirradiated Rag2 -/- mice....
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