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Huntington disease (HD) is a neurodegenerative disorder involving preferential loss of striatal GABAergic medium spiny neurons. Adenosine A 2A receptors (A 2A Rs) are present in the striatum at both presynaptic and post-synaptic levels. Blocking pre-synaptic A 2A Rs, localized in glutamatergic terminals that contact striatal GABAergic dynorphinergic neurons, reduces glutamate...
Adenosine A 2A receptors (A 2A Rs) are highly concentrated in the striatum. Two pharmacological different functional populations of A 2A Rs have been recently described based on their different affinities for the A 2A R antagonist SCH-442416. This compound has high affinity for A 2A Rs not forming heteromers or forming heteromers with adenosine A 1 receptors...
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