Search results for: Kevin Chen

Items from 1 to 20 out of 170 results

article

Rural E‐commerce and County Economic Development in China

Qiuxia Qin, Hongdong Guo, Xinjie Shi, Kevin Chen

China & World Economy > 31 > 5 > 26 - 60

With the proliferation of information and communication technology in rural areas, rural e‐commerce has gradually become a new economic phenomenon in China. Using the national rural e‐commerce comprehensive demonstration policy as a quasi‐natural experiment, this study examines the causal linkage between rural e‐commerce and county‐level economic development in China. Its findings, which draw on county‐level...

article

Relative billing complexity of in‐person versus telehealth outpatient encounters

Kevin Chen, Christine Zhang, Hannah B. Jackson

Journal of Evaluation in Clinical Practice > 29 > 6 > 887 - 892

Rationale Video visits became more widely available during the coronavirus disease (COVID‐19) pandemic. However, the ongoing role and value of video visits in care delivery and how these may have changed over time are not well understood. Aims and Objectives Compare the relative complexity of in‐person versus video visits during the COVID‐19 pandemic and describe the complexity of video visits...

article

Patient satisfaction with telehealth versus in‐person visits during COVID‐19 at a large, public healthcare system

Kevin Chen, Komal Lodaria, Hannah B. Jackson

Journal of Evaluation in Clinical Practice > 28 > 6 > 986 - 990

Rationale During the coronavirus disease pandemic, audio‐only and video telehealth visits became more widely available, but the relative patient satisfaction between telehealth and in‐person modalities is not well‐described. Aims and Objectives Our objective was to compare patient satisfaction with audio‐only, video, and in‐person adult primary care visits at a large, urban public healthcare system...

article

Topographic organization underlies intrinsic and morphological heterogeneity of central amygdala neurons expressing corticotropin‐releasing hormone

Jun‐Nan Li, Kevin Chen, Patrick L. Sheets

Journal of Comparative Neurology > 530 > 13 > 2286 - 2303

The central nucleus of the amygdala (CeA) network consists of a heterogeneous population of inhibitory GABAergic neurons distributed across distinct subregions. While the specific roles for molecularly defined CeA neurons have been extensively studied, our understanding of functional heterogeneity within classes of molecularly distinct CeA neurons remains incomplete. In addition, manipulation of genetically...

article

Associations between hospitalist physician workload, length of stay, and return to the hospital

Mia Djulbegovic, Kevin Chen, Andrew B. Cohen, Daniel Heacock, more

Journal of Hospital Medicine > 17 > 6 > 445 - 455

Background Hospitalist physicians' workload–the total number of patients they care for daily–is rising in the U.S. Hospitalists report that increased workload negatively affects patients care. Objective Measure the associations between hospitalist physicians' workload and clinical outcomes. Design, Settings, and Participants Observational study, using electronic health record (EHR) data, of adults...

article

Blood Pressure Variability Early After Liver Transplantation Predicts Long‐Term Mortality

Katie Truitt, Kevin Chen, Yuichiro Yano, Dyanna L. Gregory, more

Liver Transplantation > 28 > 4 > 615 - 622

Cardiovascular disease is a leading cause of mortality after liver transplantation (LT). Elevated blood pressure (BP) in LT recipients (LTRs) is associated with increased cardiovascular events (CVEs) and decreased survival. Increased visit‐to‐visit BP variability in the general population is associated with adverse outcomes. Whether BP variability is associated with adverse outcomes in LTRs is unknown...

article

Governmental regulation induced pesticide retailers to provide more accurate advice on pesticide use to farmers in China

Zhongju Li, Ruifa Hu, Chao Zhang, Yankun Xiong, more

Pest Management Science > 78 > 1 > 184 - 192

BACKGROUND In China, pesticide retailers have often been accused of providing inaccurate advice on pesticide use to farmers in a chaotic pesticide market. However, it is unclear whether governmental regulation of sales and advice on pesticide use by pesticide retailers induces them to provide accurate advice. RESULTS Using survey data of 242 pesticide retailers in 2016, this study analyzes how...

article

Telehealth was beneficial during COVID‐19 for older Americans: A qualitative study with physicians

Elizabeth M. Goldberg, Frances N. Jiménez, Kevin Chen, Natalie M. Davoodi, more

Journal of the American Geriatrics Society > 69 > 11 > 3034 - 3043

Background Individuals aged 65 and older face unique barriers to adoption of telehealth, and the coronavirus disease 2019 pandemic has provided a “natural experiment” in how to meet the health needs of older patients remotely. Physician perspectives on practical considerations surrounding telehealth adoption, motivations of use, and reasons for nonuse are necessary to inform the future of healthcare...

article

Impacts of Import Refusals on Agricultural Exports during Pandemics: Implications for China

Rui Mao, Ziyi Jia, Kevin Chen

China & World Economy > 29 > 4 > 113 - 141

Pandemic outbreaks disrupt agricultural trade. The possible strengthening of import barriers to products from countries at the epicenter of a pandemic by their trade partners could aggravate this situation. This paper examines the responses of the US Food and Drug Administration (FDA), import refusals, and subsequent trade impacts on the agricultural exports from the developing countries that were...

article

Pigment epithelium‐derived factor attenuates angiogenesis and collagen deposition in hypertrophic scars

Da Ma, Lin Chen, Junhe Shi, Yan Zhao, more

Wound Repair and Regeneration > 28 > 5 > 684 - 695

Scar forming wounds are often characterized by higher levels of vascularity than non‐scarring wounds and normal skin, and inhibition of angiogenesis has been shown to inhibit scar formation in some model systems. The rabbit ear hypertrophic scar (HS) model has been widely used to study the mechanisms that underlie the development of HS as well as the effectiveness of various treatments. Although the...

article

Which patients with unprovoked venous thromboembolism should receive extended anticoagulation with direct oral anticoagulants? A systematic review, network meta‐analysis, and decision analysis

Mia Djulbegovic, Alfred Ian Lee, Kevin Chen

Journal of Evaluation in Clinical Practice > 26 > 1 > 7 - 17

Introduction Direct oral anticoagulants (DOACs) effectively prevent recurrent venous thromboembolism (VTE). However, it is unknown which agents should be used to prevent recurrent VTE and which patients with unprovoked VTE should receive extended anticoagulation. We therefore sought to compare the efficacy and safety among DOACs for secondary prevention of VTE. We also determined a risk‐adapted threshold...

article

Frontline treatment of elderly non transplant‐eligible multiple myeloma patients using CyBorD with or without thalidomide‐based consolidation: a retrospective multi‐centre analysis of real‐world data

Henry Chan, Kern Chai, Steven Shih, Rebecca Lewsey, more

British Journal of Haematology > 187 > 4 > 470 - 477

Bortezomib in combination with cyclophosphamide and dexamethasone (CyBorD, is a well‐established frontline chemotherapy regimen for patients with multiple myeloma, but prospective data on elderly non‐transplant eligible patients is limited. A total of 155 patients aged 70 years or older with newly diagnosed multiple myeloma who received at least one cycle of CyBorD chemotherapy in three centres across...

article

Spin 2 operators in holographic 4d N = 2 $$ \mathcal{N}=2 $$ SCFTs

Kevin Chen, Michael Gutperle, Christoph F. Uhlemann

Journal of High Energy Physics > 2019 > 2019 > 6 > 1-15

Abstract A broad class of holographic duals for 4d N = 2 $$ \mathcal{N}=2 $$ SCFTs is based on the general half-BPS AdS₅ solutions to M-theory constructed by Lin, Lunin and Maldacena, and their Kaluza-Klein reductions to Type IIA. We derive the equations governing spin 2 fluctuations around these solutions. The resulting partial differential equations admit families of universal solutions which...

article

Relating AdS₆ solutions in type IIB supergravity

Kevin Chen, Michael Gutperle

Journal of High Energy Physics > 2019 > 2019 > 4 > 1-19

Abstract In this note we show that the IIB supergravity solutions of the form AdS₆ ×M₄ found by Apruzzi et al. in [1] are related to the local solutions found by D’Hoker et al. in [2]. We also discuss how the global regular solutions found in [3, 4] are mapped to the parameterization of [1].

article

Short‐ and long‐term potential effects of accelerated osteogenic orthodontic treatment: A systematic review and meta‐analysis

Sandeep Dab, Kevin Chen, Carlos Flores‐Mir

Orthodontics & Craniofacial Research > 22 > 2 > 61 - 68

Objective To better understand the potential effects after corticotomy accelerated osteogenic orthodontic treatment (CAOOT). Setting and sample population Systematic review with meta‐analysis. Materials and methods A literature search up to August 2018 was conducted to identify randomized clinical studies (RCTs) on CAOOT reporting periodontal parameters, bone changes, patient‐centred and short‐...

article

Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA)

Re-I Chin, Kevin Chen, Abul Usmani, Chanelle Chua, more

Molecular Diagnosis & Therapy > 2019 > 23 > 3 > 311-331

Circulating tumor DNA (ctDNA) is a component of cell-free DNA that is shed by malignant tumors into the bloodstream and other bodily fluids. Levels of ctDNA are typically low, particularly in patients with localized disease, requiring highly sophisticated methods for detection and quantification. Multiple liquid biopsy methods have been developed for ctDNA analysis in solid tumor malignancies and...

article

Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300

Kwong Wah Lai, F. Anthony Romero, Vickie Tsui, Maureen H. Beresini, more

Bioorganic & Medicinal Chemistry Letters > 2018 > 28 > 1 > 15-23

A novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP, compound 35 (GNE-207), has been identified through SAR investigations focused on optimizing al bicyclic heteroarene to replace the aniline present in the published GNE-272 series. Compound 35 has excellent CBP potency (CBP IC₅₀ = 1 nM, MYC EC₅₀ = 18 nM), a selectively index of >2500-fold against BRD4(1), and exhibits...

article

Biomechanics of the Acute Boutonniere Deformity

Luis Grau, Hasan Baydoun, Kevin Chen, Seth T. Sankary, more

The Journal of Hand Surgery > 2018 > 43 > 1 > 80.e1-80.e6

To demonstrate which structures of the extensor mechanism create a boutonniere deformity, when damaged, in a cadaver model. An analysis of how damage to these anatomical structures affects the biomechanical performance of the extensor mechanism was also performed.We secured 18 fresh cadaveric hands onto an apparatus consisting of a computer-controlled motor and tensiometer attached in series to the...

article

An Intracellular Pathogen Response Pathway Promotes Proteostasis in C. elegans

Kirthi C. Reddy, Tal Dror, Jessica N. Sowa, Johan Panek, more

Current Biology > 2017 > 27 > 22 > 3544-3553.e5

Maintenance of protein homeostasis, or proteostasis, is crucial for organismal health. Disruption of proteostasis can lead to the accumulation of protein aggregates, which are associated with aging and many human diseases such as Alzheimer’s disease [1–3]. Through analysis of the C. elegans host response to intracellular infection, we describe here a novel response pathway that enhances proteostasis...

chapter

Statistical Link Label Modeling for Sign Prediction: Smoothing Sparsity by Joining Local and Global Information

Amin Javari, HongXiang Qiu, Elham Barzegaran, Mahdi Jalili, more

2017 IEEE International Conference on Data Mining (ICDM) > 1039 - 1044

2017 IEEE International Conference on Data Mining (ICDM)

One of the major issues in signed networks is to use network structure to predict the missing sign of an edge. In this paper, we introduce a novel probabilistic approach for the sign prediction problem. The main characteristic of the proposed models is their ability to adapt to the sparsity level of an input network. Building a model that has an ability to adapt to the sparsity of the data has not...

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INFONA - science communication portal

Search results for: Kevin Chen

Rural E‐commerce and County Economic Development in China

Relative billing complexity of in‐person versus telehealth outpatient encounters

Patient satisfaction with telehealth versus in‐person visits during COVID‐19 at a large, public healthcare system

Topographic organization underlies intrinsic and morphological heterogeneity of central amygdala neurons expressing corticotropin‐releasing hormone

Associations between hospitalist physician workload, length of stay, and return to the hospital

Blood Pressure Variability Early After Liver Transplantation Predicts Long‐Term Mortality

Governmental regulation induced pesticide retailers to provide more accurate advice on pesticide use to farmers in China

Telehealth was beneficial during COVID‐19 for older Americans: A qualitative study with physicians

Impacts of Import Refusals on Agricultural Exports during Pandemics: Implications for China

Pigment epithelium‐derived factor attenuates angiogenesis and collagen deposition in hypertrophic scars

Which patients with unprovoked venous thromboembolism should receive extended anticoagulation with direct oral anticoagulants? A systematic review, network meta‐analysis, and decision analysis

Frontline treatment of elderly non transplant‐eligible multiple myeloma patients using CyBorD with or without thalidomide‐based consolidation: a retrospective multi‐centre analysis of real‐world data

Spin 2 operators in holographic 4d N = 2 $$ \mathcal{N}=2 $$ SCFTs

Relating AdS₆ solutions in type IIB supergravity

Short‐ and long‐term potential effects of accelerated osteogenic orthodontic treatment: A systematic review and meta‐analysis

Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA)

Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300

Biomechanics of the Acute Boutonniere Deformity

An Intracellular Pathogen Response Pathway Promotes Proteostasis in C. elegans

Statistical Link Label Modeling for Sign Prediction: Smoothing Sparsity by Joining Local and Global Information

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