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Background/Aim: The aim of this study was to investigate the effect of interferon gamma on the synthesis of matrix proteins such as collagens with the relation to transforming growth factor-β 1 expression in vivo.Methods: We investigated the effects of interferon gamma in a model of liver fibrosis induced by pig serum in male Wistar rats, which develops fibrosis without an increase in serum...
Background/Aims: The aim of this study was to investigate the effect and mechanism of fibrosuppression by a newly synthesized prolyl 4-hydroxylase inhibitor {HOE 077, 2, 4-pyridine dicarboxylic acids bis [(2-methoxyethyl) amide]} on pig serum-induced liver fibrosis in the rat.Methods: Male Wistar rats received 0.5 ml of pig serum twice a week for 10 weeks with 0, 100 or 200 ppm of HOE 077. At the...
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