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Generalized Pustular psoriasis (GPP), a rare and potentially life‐threatening auto‐inflammatory disease, is associated with IL36RN mutations. Here, we analyse the prevalence of IL36RN mutations in our multi‐ethnic GPP cohort and assess differences in the clinical profile of patients with (IL36RN‐positive) and without (IL36RN‐negative) mutations. IL36RN mutations were present in 17.7% of 137 GPP patients...
Background Palmoplantar pustulosis is a rare but painful and debilitating disease. It consistently ranks the highest of all psoriasis phenotypic variants in terms of symptoms and functional impairment. Management of plaque-type psoriasis has been revolutionised in the last 10 years with the advent of biologic therapies, but treatment options for pustular psoriasis remain profoundly limited. On the...
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