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Since its discovery in the late 1970s considerable research has linked transforming growth factor-beta (TGF-β) to several human diseases such as fibrosis, auto-immunity and cancer. TGF-β acts initially as a growth inhibitory factor in early stages of tumour development. In contrast, as tumours evolve, they develop mechanisms to evade the growth-regulatory effects of TGF-β, resulting in greater tumour...
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