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Hydrodynamic methods provide a route for studying the low-resolution conformation - in terms of time-averaged spatial orientation of the Fab' and Fc domains relative to each other - of the human IgG subclasses, IgG1, IgG2, IgG3 and IgG4 in the environment in which many exist naturally - a solution. Representative modelling strategies are now available using 'shell-bead' or 'shell' modelling of the...
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