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There are 3 members of the multidrug-resitance gene family expressed in mouse. Only one of these, mdr lb, and its gene product P-glycoprotein are induced to high levels in the mouse endometrium during pregnancy. It is shown here that P-glycoprotein in the gravid uterus is significantly larger (M r 155000) compared to P-glycoprotein encoded by mdr lb in a murine multidrug-resistant cell line...
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