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We recently developed a selective 11 C-labeled I 2 -imidazoline receptor (I 2 R) ligand, 2-(3-fluoro-4-[ 11 C]tolyl)-4,5-dihydro-1H-imidazole ([ 11 C]FTIMD). [ 11 C]FTIMD showed specific binding to I 2 Rs in rat brains having a high density of I 2 R, as well as to I 2 Rs those in monkey brains, as illustrated by positron emission...
The aim of this study was to visualize early infarction in the rat brain after ischemia using a translocator protein (TSPO) (18kDa) PET ligand [ 11 C]DAC with ultra-high specific activity (SA) of 3670–4450GBq/μmol. An infarction model of rat brain was prepared by ischemic surgery and evaluated 2days after ischemia using small-animal PET and in vitro autoradiography. Early infarction with a...
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