The antibiotic drug, netropsin, was complexed with the DNA oligonucleotide duplex [d(GGTATACC)] 2 to monitor drug 13 C NMR chemical shifts changes. The binding mode of netropsin to the minor groove of DNA is well-known, and served as a good model for evaluating the relative sensitivity of 13 C chemical shifts to hydrogen bonding. Large downfield shifts were observed...
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