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The activation of TLRs by microbial molecules triggers intracellular‐signaling cascades and the expression of cytokines such as IL‐10. Il10 expression is tightly controlled to ensure effective immune responses, while preventing pathology. Maximal TLR‐induction of Il10 transcription in macrophages requires signaling through the MAPKs, ERK, and p38. Signals via p38 downstream of TLR4 activation also...
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