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The aim of this study was to investigate interactions between acquired long QT syndrome by dofetilide and reduced repolarization reserve in simulated human ventricular cells using prolongation of APD and triangulation of action potential. A Markovian model of hERG capable of reproducing a wild type as well an acquired long QT syndrome by dofetilide was developed and was included into a ventricular...
During the acute phase of myocardial ischemia, electrophysiological changes and heterogeneities predispose the heart to arrhythmogenic reentrant excitation. In this computational work we analyze the role of dispersion of refractoriness on reentry generation in a two-dimensional sheet of ischemic tissue at different stages after the onset of ischemia. A realistic model of regional ischemia was used...
Traditionally, VF has been directly related to dispersion of refractoriness. However, further theoretical studies relating refractoriness and reentry generation would be helpful to understand their implication. Recently, the safety factor for conduction (SF) has been proposed as a useful parameter to analyze propagation of action potential (AP) and conduction block. In this work, the relative role...
Ventricular tachycardia and ventricular fibrillation are known to be two types of cardiac arrhythmias that usually take place during acute ischemia and frequently lead to sudden death. In this work, we have studied the different patterns of activation displayed in a virtual ventricular slab preparation after premature stimulation during acute ischemia. Furthermore, we also have analyzed the vulnerable...
The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, the estimation of the SF based on the formulation proposed by Shaw and Rudy (1997) has been extended to 2D (SF-2D) and evaluated. Furthermore, the effect of the increment of extracellular potassium concentration ([K+]o) on the SF-2D of a convex wavefront has also been studied and...
It is well known that ventricular fibrillation (VF) is a major cause of sudden cardiac death in developed countries. Myocardial regional acute ischemia constitutes a heterogeneous substrate which tends to destabilize the electrical depolarizing wave front, thus favouring VF. Functional re-entry in the transmural wall has been hypothesized as the underlying mechanism of VF. In this work, we have theoretically...
The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, we have studied the sensitivity of the SF defined by Shaw and Rudy to the integration interval (II) using computer simulations, and then defined and evaluated a new and simplified method to calculate SF (SFm). Our results reveal that the sensitivity of the SF to the II is negligible...
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