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Background and PurposeIdiopathic pulmonary fibrosis (IPF) is a progressive fibro‐proliferative disorder refractory to current therapy commonly complicated by the development of pulmonary hypertension (PH); the associated morbidity and mortality are substantial. Natriuretic peptides possess vasodilator and anti‐fibrotic actions, and pharmacological augmentation of their bioactivity ameliorates renal...
Nitric oxide (NO) plays an important role in cardiovascular homeostasis, particularly in the regulation of vascular tone and the reactivity of platelets and circulating cells. Soluble guanylate cyclase (sGC) acts as the principal biological target for NO and catalyses the formation of the intracellular second messenger cyclic GMP (cGMP); activation of this enzyme is thought to be responsible for the...
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