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INTRODUCTION: Dysfunction of the brain glutamatergic system is supposed to be one of fundamental causes underlying the schizophrenia. Administration of NMDA receptor antagonist (eg. MK801) leads to occurrence of various symptoms of that disease, inter alia, disruption of cognitive functions. AIM(S): The main aim of our study was to verify whether emotional/cognitive processes disturbed by local administration...
BACKGROUND AND AIMS: The basolateral complex of amygdala (BLA) and nucleus accumbens (NAc) are involved in acquisition and extinction of the conditioned fear. The aim of our study was to verify if the electrical activity of these structures is correlated with the behavior of rats during fear conditioning after tetrodotoxin (TTX) blockade of BLA. The disturbances of cognitive function (learning) were...
BACKGROUND AND AIMS: To examine the effect of NMDA receptor antagonists and antipsychotics on high frequency oscillations (HFO, 130–180 Hz) recorded in local field potentials from the nucleus accumbens (NAc) of freely moving mice. To identify the receptors that may underlie clozapine-induced reductions in HFO frequency. METHODS: Freely moving mice, with electrodes implanted in the NAc, received systemic...
The effect of stimuli predicting danger (DS) and safety (SS) in Pavlovian aversive conditioning on hippocampal local field potentials (LFP) was studied in 25 partially restrained adult male rats (Long-Evans). DS lasting 5 s preceded tail-shock, while SS overlapping DS during DS last 3 s predicted omission of shock. The power spectra of LFPs during trials were analyzed in theta and delta frequency...
The effect of stimuli predicting danger (DS) and safety (SS) in Pavlovian aversive conditioning on hippocampal local field potentials (LFP) was studied in 25 partially restrained adult male rats (Long-Evans). DS lasting 5 s preceded tail-shock, while SS overlapping DS during DS last 3 s predicted omission of shock. The power spectra of LFPs during trials were analyzed in theta and delta frequency...
The psychogenetically selected Roman High (RHA/Verh) and Roman Low (RLA/Verh) Avoidance rats constitute a widely accepted model of diverse emotional reactivity. They show divergent stressrelated behavioral and neuronal responses when confronted with a novel and/or stressogenic environment (Meyza et al. 2009). Here, we have explored the possibility that the difference might be also refl ected in the...
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