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Heart failure accounts for approximately 5% of all medical admissions and is the single most common cause of hospital admissions in individuals aged 65 years and over. The biochemical mechanisms for the development of heart failure are beginning to emerge. Cardiolipin is a major mitochondrial membrane phospholipid required for the activity of key mitochondrial enzymes involved in cellular energy production...
Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5′-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on mammalian cardiolipin biosynthesis and provide an overview of regulation of cardiolipin...
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