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Purpose The effects of milling and particle size on surface energies of form I paracetamol crystals are reported. Methods Paracetamol crystals (75–850 μm) were obtained by cooling methanol and acetone saturated solutions. Additionally, macroscopic (>2 cm) single crystals were grown by slow solvent evaporation from saturated solutions, ball milled and sieved into different particle size fractions...
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