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Background
Loss‐of‐function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin‐36 receptor antagonist (IL‐36Ra), has been implicated in the pathogenesis of skin disorders. However, the pathogenic role of IL‐36Ra in cutaneous ischemia‐reperfusion (I/R) injury remains unclear.
Objectives
We investigated the role of IL36Ra in cutaneous I/R injury.
Methods
We examined...