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In this study, we examined changes in bone parameters and bone strength in rats fed low-Mg diets (experiment 1) and the effects of vitamin K 2 (MK-4, experiment 3) and alendronate (ALN, experiment 2) in this model. In experiment 1, 5-week-old male Wistar rats were fed three low-Mg diets (Mg 9, 6, 3 mg/100 g diet) for 4 weeks. Although the cortical bone mineral content (CtBMC) and cortical...
Vitamin K 2 (K 2 , menatetrenone) has been reported to enhance bone formation and inhibit bone resorption in vitro. However, there is no evidence that K 2 enhances bone formation in vivo. The aim of this study was to characterize the effect of K 2 on bone formation in vivo. We carried out two experiments using a prednisolone (pred)-induced bone loss model in male (10-week-old)...
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