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Background
Flow cytometry is a well‐accepted approach for immune profiling; however, its value is restricted by the limited number of markers that can be analyzed simultaneously. Mass cytometry/CyTOF offers broad‐scale immune characterization integrating large number of parameters. While partial blood phenotyping was reported in atopic dermatitis (AD), patients’ comprehensive profiling, critical...
Background
Surfactant protein D (SPD) is a member of the collectin family that lines the airway epithelial cells with host defense. However, the role of SPD in the pathogenesis of aspirin‐exacerbated respiratory disease (AERD) is still unclear.
Methods
The serum SPD level was measured in patients with AERD (n = 336), those with aspirin‐tolerant asthma (ATA, n = 442), and healthy controls (HC, n = 104)...
Background
Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical symptoms and vary in their responses to treatments.
Methods
We applied k‐means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled in the Taiwanese Consortium of Childhood Asthma Study (TCCAS). We constructed gene...
Background
Several studies have demonstrated that allergen‐specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD.
Methods
NC/Nga mice with induced AD‐like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae...
Background
The ideal nomenclature of atopic dermatitis (AD) / atopic eczema (AE) has long been contested. However, it is becoming increasingly clear that the disparate nomenclature of this disease may have important deleterious ramifications for clinical care and research.
Materials and Methods
An electronic questionnaire regarding the preferred nomenclature for AD was sent to councilors of the...
Background
Patients with chronic granulomatous disease (CGD), whom inherit abnormal function of NADPH oxidase 2 (Nox2), suffer from hyperinflammatory responses in lung as well as bacterial and fungal infection. There have been studies to reveal the function of Nox2 in hyperinflammatory diseases, especially in asthma, but the exact role of Nox2 in asthma is still unclear and controversial. Therefore,...
BackgroundAtopic dermatitis (AD) is exacerbated by psychological factors, such as stress. We previously reported that corticotrophin‐releasing hormone (CRH) treatment in AD patients decreased the proportion of IL‐10+ Tr1 cells, a subset of inducible regulatory T cells (Tregs). However, changes in the function of Tregs in response to CRH have yet to be studied.
MethodsWe analyzed the total proteins...
BackgroundAtopic dermatitis (AD) is characterized by a heterogeneous clinical spectrum, and some forms of AD are associated with the initial steps of allergic march. The aims of this study were to determine AD phenotypes in school‐age children and investigate their associations with the allergic march in each cluster.
MethodsWe included 242 children (6–8 years) with current AD from the Children's...
Background
Sequential human herpes virus (HHV) reactivation is well known in drug reaction with eosinophilia and systemic symptom (DRESS), but such a phenomenon has seldom studied in other types of cutaneous adverse drug reactions (cADRs). Moreover, the association between viral reactivations and cytokine or chemokine changes is largely unknown. We aimed to evaluate the viral reactivation rates of...
BackgroundType 2 immune responses directed by Th2 cells and characterized by the signature cytokines IL4, IL5, and IL13 play major pathogenic roles in atopic diseases. Single nucleotide polymorphisms in the human Th2 cytokine locus in particular in a locus control region within the DNA repair gene RAD50, containing several RAD50 DNase1‐hypersensitive sites (RHS), have been robustly associated with...
BackgroundRecent evidence indicates that TNF‐α is a key mediator of the development of dsRNA‐enhanced Th2 cell response to inhaled allergens. Natural killer T (NKT) cells may be a candidate source of Th2‐polarizing cytokines.
ObjectiveThe objective of this study was to evaluate the role of lung NKT cells on the development of TNF‐α‐mediated Th2 cell response.
MethodsA virus‐associated asthma mouse...
BackgroundRecent evidence indicates that Staphylococcus aureus, one of the most important human pathogens, secretes vesicles into the extracellular milieu.
ObjectiveTo evaluate whether inhalation of S. aureus‐derived extracellular vesicles (EV) is causally related to the pathogenesis of inflammatory pulmonary diseases.
MethodsStaphylococcus aureus EV were prepared by sequential ultrafiltration and...
BackgroundMurine models suggest a critical functional role for the anti‐inflammatory cytokine IL‐10 in local regulation of allergic airways inflammation. There is little corresponding information on human airway cells. This study aimed to investigate whether local IL‐10 production regulates responses by respiratory mucosal leucocytes isolated from nasal polyps.
Materials and MethodsNasal polyp tissue...
BackgroundNasopharynx‐associated lymphoid tissue (NALT) serves as an important inductive site for mucosal immunity in the upper respiratory tract. Despite its importance in the mucosal immune system, little is known regarding the role of NALT in airway allergic immune responses. We aimed to elucidate the role of NALT in the induction of upper airway allergic responses in a mouse model.
MethodsInhibitor...
To cite this article: Mo J‐H, Kang E‐K, Quan S‐H, Rhee C‐S, Lee CH, Kim D‐Y. Anti‐tumor necrosis factor‐alpha treatment reduces allergic responses in an allergic rhinitis mouse model. Allergy 2011; 66: 279–286.
AbstractBackground: Tumor necrosis factor (TNF)‐α is a principal mediator of the acute inflammatory response, including allergic rhinitis. TNF‐α inhibitors are widely used for the treatment...
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