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BackgroundBacterial flagellin, a Toll‐like receptor 5 agonist, is used as an adjuvant for immunomodulation. In this study, we aimed to evaluate the effect and its mechanism following intralymphatic administration of OVA‐flagellin (FlaB) mixture in the mouse model of allergic rhinitis.
Materials and MethodsBALB/c mice were sensitized with OVA and treated with an OVA‐FlaB mixture via intranasal, sublingual,...
To cite this article: Kim YH, Yang TY, Park C‐S, Ahn S‐H, Son BK, Kim JH, Lim DH, Jang TY. Anti‐IL‐33 antibody has a therapeutic effect in a murine model of allergic rhinitis. Allergy 2012; 67: 183–190.
AbstractBackground: Interleukin (IL)‐33 is involved in the Th2 immune response and could play an essential role in nasal allergy. Therefore, we aimed to investigate the therapeutic...
Background
Allergic rhinitis (AR) is a very common disease and a risk factor for allergic asthma. The discovery of new biomarkers for the early detection of AR would improve the clinical outcomes and reduce socio‐economic burden. We sought to identify a novel serologic marker for detection of AR using a proteomic approach.
Methods
To identify the proteins involved in AR, comparative proteomics...
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