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BackgroundHouse dust mites (HDMs) are the most important source of indoor aeroallergens that contribute to the rising incidence of allergic diseases such as allergic asthma. The major HDM, Der f 2, induces inflammatory cytokine expression. Little is known about the signaling pathway involved.
ObjectiveWe wanted to define the Der f 2 signaling pathway from its receptor to the transcription factor...
BackgroundThe prebiotic nature of human milk oligosaccharides (HMOs) and increasing evidence of direct immunomodulatory effects of these sugars suggest that they may have some therapeutic potential in allergy. Here, we assess the effect of two HMOs, 2’‐fucosyllactose and 6’‐sialyllactose, on symptomatology and immune responses in an ovalbumin‐sensitized mouse model of food allergy.
MethodsThe effects...
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