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Immunosuppressive strategies are designed to take advantage of potential synergies between drugs to possibly decrease the risk of side-effects. In the present study, the ability of Cobalt protoporphyrin (CoPP) to potentiate the effect of the immunosuppressive drugs mycophenolate sodium (MPS) or cyclosporin A (CsA) was explored in vitro and in vivo.In vitro analyses of proliferation and apoptosis were...
In recent years the development of novel immunosuppressive strategies and new lines of engineered pigs have enabled improved xenograft survival in the clinically-relevant pig-to-primate models (especially in islet xenotransplantation). Furthermore, researchers have now developed appropriate biomolecular tools to address rapidly the remaining barriers and render organs from source pigs more “compatible”...
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