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BackgroundWe investigated whether graft produced anti‐human CD2, mediated by adenovirus (Adv) transduction of pig neonatal islet cell clusters (pNICC), would protect xenografts in a humanized mouse model from immune attack and whether such immunosuppression would remain local.
MethodsA mouse anti‐human CD2 Ab (CD2hb11) previously generated by us was genetically engineered to produce chimeric and...
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