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Furano‐1,2‐naphthoquinone (FNQ), prepared from 2‐hydroxy‐1,4‐naphthoquinone and chloroacetaldehyde in an efficient one‐pot reaction, exhibits an anti‐carcinogenic effect. FNQ exerted anti‐proliferative activity with the G2/M cell cycle arrest and apoptosis in A549 cells. FNQ‐induced G2/M arrest was correlated with a marked decrease in the expression levels of cyclin A and cyclin B, and their activating...
Humanin (HN) is a newly identified neuroprotective peptide. In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells. Upon serum deprivation, expression of HN in K562 cells decreased and its intracellular distribution changed from cytoplasm to cell membrane. In HN stably transfected K562 cells, apoptosis was delayed compared with control vector transfected...
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