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A three-dimensional cardiomyocyte gel was reconstructed using an extracellular matrix gel formed from Matrigel and collagen I. The autonomous beating of the cardiomyocyte gel was synchronized with contraction of cardiomyocytes in the gel. The gel beating frequency was increased by increasing the concentration of adrenaline in the cardiomyocyte culturing medium. Drug stimulation to modulate the beating...
This paper describes assembly of three dimensional cellular structure by optical tweezers. We attempted to construct a three dimensional quasi living machine in small space with muscle cells. Cardiomyocytes were manipulated by using laser optical tweezers at wavelength of 1064 nm. The cellular bridge structure was successful constructed on between PDMS micro pillars. The viability and contraction...
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