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The Ras‐related C3 botulinum toxin substrate 1 (RAC1), a member of the Rho family of small guanosine triphosphatases, is critical for many cellular activities, such as phagocytosis, adhesion, migration, motility, cell proliferation, and axonal growth. In addition, RAC1 plays an important role in cancer angiogenesis, invasion, and migration, and it has been reported to be related to most cancers, such...
COX-2 is a major regulator in colorectal inflammation and cancer. Herein, we first report that primary cancer-associated colonic fibroblasts activated by HGF play a critical role in mediation of proliferation and invasiveness of human colonic epithelial cancer cells. We have discovered that the proliferation and invasiveness of colonic epithelial cancer cells are predominantly enhanced through activation...
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