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PU.1 and Spi-B have previously been implicated in the regulation of genes encoding B cell receptor (BCR) signaling components. Spi-B -/- B lymphocytes respond poorly to BCR stimulation; PU. 1 / mice, however, lack B cells, precluding an analysis of BCR responses. We now show that PU.1 +/- Spi-B -/- B cells exhibit more extensive defects...
We have previously shown using gene targeting that PU.1 is essential for the development of lymphoid and myeloid lineages during fetal liver hematopolesis. We now show that PU.1 is required for the maturation of yolk sac-derived myeloid progenitors and for the differentiation of ES cells into macrophages. The role of PU.1 in regulating target genes, thought to be critical in the development of monocytes...
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